Tirzepen
Tirzepen 5mg
Tirzepen 5mg
Quickstart Highlights
Tirzepen 5mg is a dual incretin receptor agonist that activates both GLP‑1 and GIP receptors, enhancing glucose‑dependent insulin secretion, suppressing glucagon, slowing gastric emptying, and reducing appetite. Its ~5‑day half‑life allows convenient once‑weekly subcutaneous dosing.
- 1Reconstitute: Add 2.0 mL bacteriostatic water → 2.5 mg/mL concentration.
- 2Typical weekly range: 2.5–15 mg once weekly (gradual 4‑week titration steps).
- 3Easy measuring: At 2.5 mg/mL, 1 unit = 0.01 mL = 25 mcg on a U‑100 insulin syringe.
- 4Storage: Freeze lyophilized powder at −20 °C; refrigerate reconstituted liquid at 2–8 °C (use within 28 days).
Dosing & Reconstitution Guide
Standard gradual approach for Tirzepen 5mg
Standard / Gradual Approach (2 mL = 2.5 mg/mL)
| Phase | Weekly Dose | Units (per injection) |
|---|---|---|
| Weeks 1–4 | 2.5 mg | 100 units (1.0 mL) × 1 injection |
| Weeks 5–8 | 5 mg | 100 units (1.0 mL) × 2 injections |
| Weeks 9–12 | 7.5 mg | 100 units (1.0 mL) × 3 injections |
| Weeks 13–16 | 10 mg | 100 units (1.0 mL) × 4 injections |
Frequency: Inject once weekly subcutaneously on the same day each week. Dose increases occur every 4 weeks to minimize gastrointestinal side effects.
Reconstitution Steps
- Draw 2.0 mL bacteriostatic water with a sterile syringe.
- Inject slowly down the vial wall; avoid foaming.
- Gently swirl/roll until dissolved (do not shake).
- Label with reconstitution date and refrigerate at 2–8 °C, protected from light.
- Use within 28 days of reconstitution.
Protocol Overview
- Goal: Support glycemic control, weight management, and metabolic health.
- Schedule: Weekly subcutaneous injection on the same day each week.
- Dose Range: 2.5–15 mg weekly with 4‑week titration intervals.
- Reconstitution: 2.0 mL per 5 mg vial (2.5 mg/mL).
Dosing Protocol
- Start: 2.5 mg once weekly for 4 weeks.
- Escalate: Increase by 2.5 mg every 4 weeks as tolerated.
- Maintenance: 5–15 mg weekly based on response.
- Timing: Any time of day; with or without food.
Storage
- Lyophilized: Store at −20 °C (−4 °F) in dry, dark conditions.
- Reconstituted: Refrigerate at 2–8 °C; do not freeze liquid.
- Shelf life: Use reconstituted solution within 28 days.
How This Works
Tirzepen is a novel dual agonist that simultaneously activates GLP‑1 (glucagon‑like peptide‑1) and GIP (glucose‑dependent insulinotropic polypeptide) receptors. This dual mechanism enhances glucose‑dependent insulin secretion while suppressing glucagon release, slowing gastric emptying, and promoting satiety through central appetite regulation. The added GIP activity appears to synergistically amplify metabolic effects beyond GLP‑1 alone.
Potential Benefits & Side Effects
- Glycemic control: Significant HbA1c reductions observed.
- Weight reduction: Substantial body‑weight loss reported in trials.
- Cardiovascular markers: Potential improvements in lipid profiles and blood pressure.
- Common side effects: Gastrointestinal (nausea, diarrhea, constipation) — typically mild‑to‑moderate.
- Injection‑site reactions: Occasional mild redness or irritation.
